Sulfhydryl compounds such as cysteine, reduced glutathione gsh, and cysteamine prevented the lesion formation induced by acidified ethanol. Adverse effects of the drugs were calculated based on ulcer index. Studies showed hypoglycemic effect of catalpol in streptozotocin induced diabetic rats. Effect of ethanolic extract of coconut cocos nucifera on aspirin. Oral administration of camel milk in rats with ethanolinduced gastric ulcer. Evaluation of anti ulcer activity of ethanolic extract of. The anti ulcer study was evaluated using ethanol induced gastric ulcer in rats. This study investigated the protective effects of assyrian plum cordia myxa l. Nsaids and aspirin are the other major risk factors. Gastric ulcers were induced in sprague dawley rats using one oral dose of absolute. By the activation of notch1 signaling pathway catalpol renders a protective effect on cardiotoxic rats39. Hatlebakk, 2 dorisgundersen, 4 andtrygvehausken 2 sectionforgastroenterology,departmentofmedicine,stordhelsefonnahospital,p.
The abdomen was opened and the stomach was visualized. This approach can be used to test for gastrointestinal side effects of potential anti. Evaluation of cytoprotective properties of sodium cromoglycate on ethanol induced ulcer was performed in albino rats. The elderly population has experienced increased life expectancy as well as the increased incidence of gastric ulcers. Gastric ulcers were induced in albino rats by pyloric ligation as described. Gastric ulcers were induced in wistar albino rats by oral administration of indomethacin 200 mgkg, alcohol 80%, 1 ml100 gm and by pyloric ligation. Gastric ulcer is one of the most serious diseases in the world. Thirty rats, weighing 175220 gm, were divided into six groups and were treated with different. The aqueous extract of ocimum sanctum at the dose rate of 100mg kg an 200 mgkg per orally exhibited significant protection against ethanol induced gastric ulceration. Antiulcerogenic activity of scutia buxifolia on gastric. Several orthodox drugs are employed for the treatment of the disease. Gastroprotective effect of hydroalcoholic extract of polygonum bistorta linn root hepb was investigated in indomethacininduced gastric ulcer in sprague dawley rats.
The ethanolic extract of commiphora caudata bark extract was evaluated for their cytoprotective activity against ethanolinduced gastric lesions in rats. Pdf antiulcerogenic activity of scutia buxifolia on gastric. The acetone extract of cucumis sativus seed reduces the paw edema induced by carrageenan by 43. Ethanolinduced gastric ulceration, acetic acidinduced writhing and formalininduced nociception were used. Chandra p, sachan n, gangwar ak and sharma pk, comparative study of mineraloherbal drugs kamadugha and sutshekhar rasa sada on gastric ulcer in experimental rats, journal of pharmacy research, 2010. The effect of nicotine on ethanolinduced gastric ulcers in rats. In this study, the preventive effects of the crude extract of scutia buxifolia cesb against gastric ulcer induced by 70% ethanol were evaluated in male wistar rats. Thus, hepb possesses gastroprotective effect against indomethacin induced gastric ulcers in. Tac302, cyclohexenoiclong fatty alcohol derivative, is a novel neurite outgrowth enhancer which has a beneficial effect on not only central nerve system disorder, but also peripheral neuropathy. Aqueous extract of ocimum sanctum was evaluated for its antiulcer activity against methanol induced ulcer in wistar rats. Purified oleuropein from olive leaf extract has been shown to have antioxidant effects in our recent studies. The ethanolic extract of commiphora caudata bark extract was evaluated for their cytoprotective activity against ethanol induced gastric lesions in rats. Health, general biological sciences science and technology, general antiulcer agents research antiulcer drugs loganiaceae health. Anti diabetic activity of ethanolic extract of aconitum ferox.
A zinc morpholine complex prevents hclethanolinduced. Hepb protected stomach from indomethacin induced gastric ulcers in rats by prevention of induced mucooxidative stress. To estimate the antiulcer activity of leaves of musa. Ulceration was induced by a single oral administration of indomethacin 30 mgkg body weight.
It is also reported that tac302 improved nerve velocity conductance in rats with diabetic mellitus dm induced by streptozotocin stz. Gastroprotective effect of zingerone on ethanolinduced gastric. Histochemical studies of the efficacy of an antiulcer herbal. The present study was performed to evaluate the efficacy and toxic effect of an antiulcer herbal mixture. Evaluation of pongamia pinnata root extract on gastric ulcers. Protective effect of falcaria vulgaris extract on ethanol. Effect of n nitrosodiethylamine administration on liver of wistar rats joice p. Anti diabetic activity of ethanolic extract of aconitum ferox in alloxan induced diaseased rats j kondal reddy1, p sheetal2, rajesh menda2, nukala aparna3 1department of pharmacology, vision college of pharmaceutical sciences, boduppal, hyderabad, india. Protective effects of barley and its hydrolysates on. Antioxidant can donate a hydrogen atom to reduce free radi.
The effects of aqueous leaf extracts of sm and fe on the ulcer index and % inhibition against ulcer in the experimental animals are shown in fig. The results obtained indicate that the acetone extract has significant antiinflammatory activity in rats. Protective effects of barley and its hydrolysates on gastric. Ulcer index was assessed in 100150 gm fasted albino rats after administration of ethanol. Antiulcerogenic effect of camel milk against ethanol induced. Research article amelioration of severe tnbs induced. Beneficial effects of nacetylcysteine on acetic acidinduced colitis in rats ali cetinkaya, ertan bulbuloglu, 1 ergul belge kurutas, 2 harun ciralik,3 bulent kantarceken 4 and mehmet akif buyukbese department of internal medicine, 1department of general surgery, 2department of biochemistry, 3department of pathology and 4department of gastroen. Studies showed hypoglycemic effect of catalpol in streptozotocininduced diabetic rats. The control group in the acute toxicity study received 2 ml of distilled water. Antiulcerogenic potential of strychnos potatorum linn seeds on aspirin plus pyloric ligationinduced ulcers in experimental rats. Administration of ethanolic extract of aegle marmelos and standard drug omeprazole both produced highly significant p ulcer effect compared to control group.
Gastric ir injury was induced according to wada et al. Evaluation of antiinflammatory and gastric antiulcer. Protection of ethanol induced ulcers by sodium cromoglycate. These results suggested a possible benefit of milk supplementation in treating peptic ulcer. Health, general biological sciences science and technology, general antiulcer agents research. Beneficial effects of nacetylcysteine on acetic acid. In addition, the composition of cesb was clarified by highperformance liquid chromatography hplc.
Histochemical studies of the efficacy of an antiulcer. Balakrishnan1 school of biomedicine 1, asia metropolitan university, g8, jalan kemacahaya 11, batu 9, 43200 cheras, selangor, malaysia. Balakrishnan 1 school of biomedicine 1, asia metropolitan university, g8, jalan kemacahaya 11, batu 9, 43200 cheras, selangor, malaysia. Santha maria1, surya devarakonda 1, ajay kumar tv 2 and n. To study antiulcer effect of amlodipine and compared it with ranitidine in indomethacin, alcohol and pyloric ligationinduced gastric ulcers in wistar rats.
Therapeutic value of camel milk as antiulcerogenic effect. I gastric lesions induced by ethanol cytoprotection studies rats will be randomly divided in to 5 groups of 6 rats in each group and treated as follows. Polygonum bistorta has been used as hemostatic drug in unani system of medicine due to its cold and dry temperament. A cylindrical glass tube 6 mm in diam was tightly placed upon the anterior. Antiulcerogenic activity of scutia buxifolia on gastric ulcers induced by ethanol in rats. Evaluation of antiulcer effect of amlodipine in gastric. The gastro protective effects of cibotium barometz hair on ethanol. Methods for induction of peptic ulcer in animal models water immersion induced stress wis the rats were fasted for 24 h before inducing the ulcer and test samples were administered 1 h prior to stress induction. Antiulcerogenic activity of commiphora caudata bark. This research intends to clarify the protective effect of barley and its hydrolysates with respect to a water immersion stressinduced ulcer in the rat model. The ulcer index parameter was used for the evaluation of ulcer activity. Potential effect of citrus decumana extract on stress.
Protective effect of falcaria vulgaris extract on ethanol induced gastric ulcer in rat ijpt. Treatment with prostaglandin e 2 pge 2, but not cimetidine, prevented the formation of gastric mucosal lesions. Asuzu2 1department of veterinary pharmacology and toxicology, university of abuja, pmb 117 abuja, nigeria. Thus, in the present study we used antineutrophil serum to assess the role of neutrophils in ethanol induced injury to the gastric mucosa. In recent years, there has been a growing interest in alternative therapies, especially those from plants due to their perceived relative lower side. Antiulcer effect of amlodipine and its interaction with h2 blocker and. The participation of polyamines and nonprotein sulfhydryls in the gastric cytoprotective mechanisms was studied using gastric mucosal lesions produced by acidified ethanol in rats as an experimental model. Research article amelioration of severe tnbs induced colitis by novel ap1 and nf b inhibitors in rats magdyelsalhy, 1,2 kazuoumezawa, 3 oddhelgegilja, 2 jang. Antiulcer study coldrestraint stress crsinduced gastric ulcers gu to 18 h fasted rats, cold restraint stress was given by strapping the rats on a wooden plank and keeping them for 2 h at 46 c. Ulcer healing study acetic acid induced ulcersfor induction of ace tic acid ulcer, the method was followed as reported earlierl. Effect of methanolic extract of pongamia pinnata linn seed.
Albino rats were fasted for a period of 24 h, allowing free access to drinking water ad libitum prior to drug administration and divided into four groups of six animals. Peptic ulcer is among the most serious gastrointestinal diseases in the world. In both models the common parameter determined was ulcer index. Finally, the same positive effect of the oral administration of camel milk was observed in rats with naproxen induced peptic ulcers. The effect of znlscn on the ulcer area induced by hcl ethanol is shown in fig.
Abstractapproximately 60% of morphine is glucuronidated to morphine3glucuronide m3g which may aggravate preexisting. Compared with non users, nsaid and aspirin use increase the risk of complications of peptic ulcer disease by four times in nsaid users, and by two times in aspirin users. Beneficial effects of nacetylcysteine on acetic acid induced colitis in rats ali cetinkaya, ertan bulbuloglu, 1 ergul belge kurutas, 2 harun ciralik,3 bulent kantarceken 4 and mehmet akif buyukbese department of internal medicine, 1department of general surgery, 2department of biochemistry, 3department of pathology and 4department of gastroen. The ethanol extract of gongronema latifolium leaves were evaluated for antiulcer, analgesic and anti pyretic activities in rats and mice. Although these drugs are effective, they produce many adverse effects thus limiting their use. Antiulcerogenic effect of cuphea ignea extract against ethanol. Ulcer index was calculated by adding the total number of ulcers. Although there are many drugs used for the treatment of gastric ulcer, most of these produce several adverse reactions.
The ulcer areas seen in the rats treated with znlscn were significantly lower p pdf available via license. Effect of methanolic extract of pongamia pinnata linn seed on. The effect of znlscn on the ulcer area induced by hclethanol is shown in fig. Ulcer protection potency of hepb mgkgday in groupiv was comparable to that of 20 mgkgday ranitidine in groupv. The ameliorative effect of dates phoenix dactylifera l. We evaluated the healing effects of essential oil from the peels. Evaluation of antiulcer activity of ocimum sanctum in rats. Biochanin a gastroprotective effects in ethanolinduced. Gastric ulcers were induced by ethanol 96%, 5 mlkg, po in male wistar rats and zingerone 50, 100, and 200 mgkg. Potential effect of citrus decumana extract on stress induced. The anti ulcer activity of methanolic extract of terminalia chebula combretaceaefruits metc was investigated in pylorus ligation and ethanol induced ulcer models in wistar rats. A novel antioxidant and antiapoptotic role of omeprazole to. Yeastinduced hyperpyrexia was used to investigate the antipyretic activity.
Each was orally treated respectively with distilled water ulcer control group, omeprazole 20mgkg reference group and 100, 200, 400 and 800mgkg extract from idogun antiulcer. The effect of oral administration of raw camel milk 5 mlkg b. We evaluated the healing effects of essential oil from the. Ranitidine had similar effect compared to mear 400mgkg bw. Gastroprotective effect of hydroalcoholic extract of.
This unit describes a procedure to elicit and measure indomethacin. The animals were then sacrificed by cervical dislocation17. Evaluation of antiulcer activity of methanolic extract of. Antiulcerogenic activity of commiphora caudata bark extract. A preliminary study of the antiinflammatory and anti. This study investigated the quantitative polyphenolic constituents and gastroprotective effects of aqueous leaf extracts of spondias mombin and ficus exasperata against indomethacin induced gastric ulcer in rats. Short communication, clinical report by phytomedicine.
Quantitative phytochemical analysis was carried out on the ethanol extract of the herbal mixture. Fruit pulp extract on indomethacininduced gastric ulcer in albino. Thus, the aim of this study was to assess the antioxidant abilities of oleuropein in comparison with ranitidine in ethanol induced gastric damages via evaluation of ulcer index inhibition, antioxidant enzyme activities, and lipid peroxidation level. Similarly, rats prefed with morus alba extract for 4 days displayed significant low ulcer index, with a protective efficacy comparable to lansoprazole, in an ethanol induced ulcer model ahmad et. Administration of ethanolic extract of aegle marmelos and standard drug omeprazole both produced highly significant p free online library. Group i animals were pretreated with phosphate buffer saline 5 mlkg, p.
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